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Grant support

The authors thank the Spanish Ministry of Education and Science for supporting this work through project MAT2006-11516. Support for the research of MPG was received through the prize "ICREA Academia" for excellence in research, funded by the Generalitat de Catalunya E B. Montufar acknowledges the Ph.D. scholarship from the Mexican Council for Science and Technology (CONACyT).

Analysis of institutional authors

Ginebra, MpCorresponding AuthorEspanol, MAuthorMontufar, EbAuthorPerez, RaAuthorMestres, GAuthor
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Review

New processing approaches in calcium phosphate cements and their applications in regenerative medicine

Publicated to:Acta Biomaterialia. 6 (8): 2863-2873 - 2010-08-01 6(8), DOI: 10.1016/j.actbio.2010.01.036

Authors: Ginebra, MP; Espanol, M; Montufar, EB; Perez, RA; Mestres, G

Affiliations

Biomaterials for Regenerative Therapies. Institute for Bioengineering of Catalonia - Author
CIBER BBN, Zaragoza 50118, Spain - Author
Inst Bioengn Catalonia, Barcelona 03028, Spain - Author
Institute for Bioengineering of Catalonia - Author
Tech Univ Catalonia, UPC, Dept Mat Sci & Met, Biomat Biomech & Tissue Engn Grp,ETSEIB, E-08028 Barcelona, Spain - Author
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Abstract

The key feature of calcium phosphate cements (CPCs) lies in the setting reaction triggered by mixing one or more solid calcium phosphate salts with an aqueous solution Upon mixture, the reaction takes place through a dissolution-precipitation process which is macroscopically observed by a gradual hardening of the cement paste The precipitation of hydroxyapatite nanocrystals at body or room temperature, and the fact that those materials can be used as self-setting pastes, have for many years been the most attractive features of CPCs However, the need to develop materials able to sustain bone tissue ingrowth and be capable of delivering drugs and bioactive molecules, together with the continuous requirement from surgeons to develop more easily handling cements, has pushed the development of new processing routes that can accommodate all these requirements, taking advantage of the possibility of manipulating the self-setting CPC paste. It is the goal of this paper to provide a brief overview of the new processing developments in the area of CPCs and to identify the most significant achievements (C) 2010 Acta Materialia Inc Published by Elsevier Ltd All rights reserved.

Keywords
BiocompatibilityBiodegradationBioleachingBiomaterialBone cementBone cementsBone graftBone regenerationBone responseCalcium derivativeCalcium phosphateCalcium phosphate cementCalcium phosphate cementsCalcium phosphate ceramicCalcium phosphatesCarbon dioxideChemical reactionCompositeDicalcium phosphate anhydrousDrug activityDrug delivery systemDrug formulationEmulsionFabricationFoamingFoaming agentFreeze dryingGasGelatinGranule cellGranulesHumanHydrogen peroxideHydrolysisHydroxyapatiteHydroxyapatite scaffoldsHydroxypropylmethylcelluloseImplantationIn vivo cultureLiquid phase microextractionMaterials testingMethodologyMicrocarrier cultureMicrocarriersNanofabricationNonhumanPhysical-propertiesPlgaPolyglactinPolymerizationPolyurethanPorous hydroxyapatitePowderPriority journalProcess developmentRegenerative medicineReinforcementReviewScaffoldsSurface propertySurfactantSynthesisTetracalcium phosphateTissue engineeringTissue scaffoldTissue scaffoldsTransforming growth factor beta1Tricalcium phosphateUnclassified drug

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Acta Biomaterialia due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2010, it was in position 3/70, thus managing to position itself as a Q1 (Primer Cuartil), in the category Engineering, Biomedical.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 27.53, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Apr 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-04-29, the following number of citations:

  • WoS: 250
  • Scopus: 270
  • Europe PMC: 103
  • OpenCitations: 251
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-04-29:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 391 (PlumX).
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Ginebra Molins, Mª Pau) and Last Author (Mestres Beà, Gemma).

the author responsible for correspondence tasks has been Ginebra Molins, Mª Pau.